Will report this to NextDNS also however it seems block bypass methods is blocking *.mask-api.icloud.com which is now needed for new Siri.
Putting this on the whitelist fixes it and iCloud private relay is still blocked as the main mask addresses still are:
mask.icloud.com mask-h2.icloud.com
Hope this helps someone! Was driving me crazy.
Source: r/nextdns · by /u/Lammiroo