The best comprehensive blocklists. This is all you need. Set and forget. My recommendation.

OISD + Hagezi Multi Normal + Adguard DNS filter

This is me speaking with years of experience and knowledge of my own I gathered over the years
These 3 blocklists work well together.
Now you’ll think that adding either will make the other 2 redundant or vice versa. That is not the case because:
Sometimes literally only OISD blocks some particular domains
Some domains are literally only blocked by Hagezi Multi Normal and lastly some are only blocked by Adguard DNS filter.

Some of you will suggest to you Hagezi Pro or Pro++. I wouldn’t suggest these because even though you wouldn’t usually find any issues. Well mostly at least for Hagezi Pro. I still wouldn’t suggest Hagezi Pro++ or Ultimate. Not worth it in my opinion. More false positive chances. Hagezi Pro, Pro++ & Ultimate block important domains that you wouldn’t immediately notice or sense, but you will feel during browsing its blocking or getting in important tracking or domains that are meant for proper functionality.
Me personally I want my stuff to work as intended without really having to worry that one of my blocklist blocked something that is legit and I use.

The great thing about these 3 lists are that they block most ads and trackers and even hidden annoying trackers and pop ups etc. They work very well together as I mentioned. Another great thing is all 3 don’t break your regular usage and all are updated and curated every day. They don’t get in your way and give you a clean and private browsing experience in either your browser or apps. Extremely rare chance of a false positive.
You are 99% good to go.
Thank you for reading and try it out.